POSTGRADUATE STUDIES IN MOLECULAR MEDICINE IN MALAYSIA: CHALLENGES AND FUTURE PERSPECTIVE(Pengajian Pascasiswazah dalam Perubatan Molekul di Malaysia: Cabaran dan Perspektif Masa Depan)

Nor Azian Abdul Murad, Chin Siok Fong, Muhammad-Redha Abdullah-Zawawi, Rahman Jamal

Abstract


ABSTRACT

Molecular Medicine consists of a broad range of fields involving physical, chemical, biological and bioinformatics to identify the fundamental issues in medicine. This includes understanding diseases at the molecular level and developing strategic interventions and treatment via personalized and precision medicine. In Malaysia, private and public universities offer a postgraduate Molecular Medicine program. Universiti Kebangsaan Malaysia offers this program through the Faculty of Medicine and UKM Medical Molecular Biology Institute (UMBI) via various research projects involving non-communicable diseases (cancer and non-cancer) and infectious diseases. Several challenges will be discussed, including limited research funding and competitive grant applications, particularly international grants. Research funding is necessary, impacting the quality of postgraduate research. Second, the infrastructure and access to the needed reagents could be improved since most companies providing these services are from the USA, European countries and the United Kingdom. In addition, the instruments are expensive, and the technology evolved too fast. Third, an innovative partnership between academia and industries must be enhanced to support the research ecosystem better. The biotechnology companies may also provide a  place for attachment for the students to experience the working culture in industries, apart from their formal education in the university. Pursuing postgraduate studies in Molecular Medicine still offers a valuable experience for students, even with these significant obstacles. These challenges can be overcome via several strategies, which will be discussed in the article.

ABSTRAK

Perubatan Molekul terdiri daripada pelbagai bidang yang melibatkan fizikal, kimia, biologi dan bioinformatik untuk mengenal pasti isu asas dalam perubatan. Ini termasuklah memahami penyakit di peringkat molekul dan membangunkan kaedah strategik bagi merawat pesakit melalui perubatan yang diperibadikan. Di Malaysia, pelbagai universiti swasta dan awam menawarkan program Perubatan Molekul di peringkat pascasiswazah. Universiti Kebangsaan Malaysia menawarkan program ini melalui Fakulti Perubatan dan Institut Biologi Molekul Perubatan UKM (UMBI) melalui pelbagai projek penyelidikan yang melibatkan penyakit tidak berjangkit (kanser dan bukan kanser) dan penyakit berjangkit. Beberapa cabaran akan dibincangkan, termasuklah pembiayaan penyelidikan yang terhad dan permohonan geran yang kompetitif, terutamanya geran antarabangsa. Pembiayaan penyelidikan adalah perlu, yang akan memberi kesan kepada kualiti penyelidikan pascasiswazah itu sendiri. Kedua, infrastruktur dan akses kepada reagen yang diperlukan boleh dipertingkatkan kerana kebanyakan syarikat yang menyediakan perkhidmatan ini adalah dari Amerika Syarikat, negara Eropah dan United Kingdom. Di samping itu, instrumen yang mahal, dan teknologi bidang ini berkembang dengan begitu pesat. Ketiga, perkongsian inovatif antara akademia dan industri mesti dipertingkatkan untuk menyokong ekosistem penyelidikan dengan lebih baik. Syarikat bioteknologi juga boleh menyediakan tempat untuk para pelajar merasai budaya kerja di industri, selain daripada pendidikan formal di universiti. Sebagai kesimpulan. melanjutkan pengajian di peringkat pascasiswazah dalam Perubatan Molekul masih menawarkan pengalaman berharga untuk pelajar, walaupun dengan cabaran yang bakal dihadapi. Cabaran ini boleh diatasi melalui beberapa strategi, yang akan dibincangkan dalam artikel ini.


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References


Bernasconi, A. 2021. Data quality-aware genomic data integration. Computer Methods and Programs in Biomedicine Update 1(100009): 1-12. doi:https://doi.org/10.1016/j. cmpbup.2021.100009.

Bianconi, V., Banach, M. & Pirro, M. 2021. Why patients with familial hypercholesterolemia are at high cardiovascular risk? Beyond LDL-C levels. Trends in Cardiovascular Medicine 31(4): 205-215. doi:https://doi.org/10.1016/j.tcm.2020.03.004.

Bohr, A. & Memarzadeh, K. 2020. The rise of artificial intelligence in healthcare applications. In Bohr, A. & Memarzadeh, K. (ed.). Artificial Intelligence in Healthcare, pp. 25-60. United Kingdom: Academic Press.

Chen, C., Wang, J., Pan, D., Wang, X., Xu, Y., Yan, J., Wang, L., Yang, X., Yang, M. & Liu, G.P. 2023. Applications of multi-omics analysis in human diseases. MedComm 4(e315): 1-32. doi:10.1002/mco2.315.

Chua, Y.A., Razman, A.Z., Ramli, A.S., Mohd Kasim, N.A. & Nawawi, H. 2021. Familial Hypercholesterolaemia in the Malaysian Community: Prevalence, Under-Detection and Under-Treatment. Journal of Atherosclerosis and Thrombosis 28(10):1095-1107.doi:10.5551/jat. 57026.

Cohen, H. & Stefanutti, C. 2021. Current Approach to the diagnosis and treatment of heterozygote and homozygous FH children and adolescents. Current Atherosclerosis Reports 23(30): 1-14. doi:10.1007/s11883-021-00926-3.

Dash, S., Shakyawar, S.K., Sharma, M. & Kaushik, S. 2019. Big data in healthcare: management, analysis and future prospects. Journal of Big Data 6(1): 1-25.doi:10.1186/s40537-019-0217-0.

Fan, J., Han, F. & Liu, H. 2014. Challenges of Big Data Analysis. National Science Review 1(2): 293-314. doi:10.1093/nsr/nwt032.

Fong, F. 2016. Higher Education Ministry maintains aim of producing 60,000 PhD holders by 2023. New Straits Times, 1 November. https://www.nst.com.my/news/2016/11/184937/ higher-education-ministry-maintains-aim-producing-60000-phd-holders-2023.

Johnson, K.B., Wei, W.Q., Weeraratne, D., Frisse, M.E., Misulis, K., Rhee, K., Zhao, J. & Snowdon, J.L. 2021. Precision medicine, AI and the future of personalized health care. Clinical and Translational Science 14(1): 86-93. doi:10.1111/cts.12884.

Kanzi, A.M., San, J.E., Chimukangara, B., Wilkinson, E., Fish, M., Ramsuran, V. & de Oliveira, T. 2020. Next Generation Sequencing and Bioinformatics Analysis of Family Genetic Inheritance. Frontiers in Genetics 11(544162): 1-18. doi:10.3389/fgene.2020.544162.

Kulkarni, P. & Frommolt, P. 2017. Challenges in the setup of large-scale nextgeneration sequencing analysis workflows. Computational and Structural Biotechnology Journal 15: 471-477. doi:10.1016/j.csbj.2017. 10.001.

Marques, L., Costa, B., Pereira, M., Silva, A., Santos, J., Saldanha, L., Silva, I., Magalhães, P., Schmidt, S. & Vale, N., 2024. Advancing precision medicine: A review of innovative in silico approaches for drug development, clinicalpharmacology and personalized healthcare. Pharmaceutics 16 (3): 1-39.doi:10.3390/pharmaceutics16030332.

Medeiros, A.M. & Bourbon, M. 2023. Genetic testing in familial hypercholesterolemia: Is it for everyone? Current Atherosclerosis Reports 25 (4): 127-132. doi:10.1007/s11883-023-01091-5.

National Human Genome Research Institute. 2022. Human genome project. https://www.genome.gov/about-genomics/educational-resources/fact-sheets/ humangenome- project.

National Human Genome Research Institute. 2023. The Human Genome Project. https://www.genome.gov/human-genome-project.

National Library of Medicine. 2003. Collection development guidelines of the National Library of Medicine.https://www.ncbi.nlm.nih.gov/books/ NBK518704/.

Pena, S.D.J. & Tarazona-Santos, E. 2022. Clinical genomics and precision medicine. Geneticsc and Molecular Biology 45(3): 1-8. doi:10.1590/1678-4685-gmb-2022-0150.

Anon. 2023. PhD holders in natural sciences, maths record lowest employment in 2022. Sinar Daily, 27 March. https://www.sinardaily.my/article/192782/focus/ national/phd-holders-in-natural-sciences-maths-record-lowest-employmentin-2022.

Hanna, R. 2023. Structuring your day as a postgraduate student. University of Birmingham, 28 March. https://www.pg.bham.ac.uk/blog/ structuring-your-dayas-a-postgraduate-student/.

Ristevski, B. & Chen, M. 2018. Big Data analytics in medicine and healthcare. Journal of Integrative Bioinformatics 15(3): 1-5. doi:10.1515/jib-2017-0030.

Rogozik, J., Główczyńska, R. & Grabowski, M. 2024. Genetic backgrounds and diagnosis of familial hypercholesterolemia. Clinical Genetics 105(1): 3-12. doi:10.1111/cges.14435.

Satam, H., Joshi, K., Mangrolia, U., Waghoo, S., Zaidi, G., Rawool, S., Thakare, R.P., Banday, S., Mishra, A.K., Das, G. & Malonia, S.K. 2023. Next-generation sequencing technology: Current trends and advancements. Biology 12(7): 1-25. doi:10.3390/biology12070997.

Tomlinson, B., Patil, N.G., Fok, M. & Lam, C.W.K. 2021. Role of PCSK9 inhibitors in patients with familial hypercholesterolemia. Endocrinol Metab (Seoul) 36(2): 279-295. doi:10.3803/EnM.2021.964.

Vrablik, M., Tichý, L., Freiberger, T., Blaha, V., Satny, M. & Hubacek, J. A. 2020. Genetics of familial hypercholesterolemia: New insights. Frontiers in Genetics 11: 1-10. doi:10.3389/fgene.2020.574474.




DOI: http://dx.doi.org/10.17576/JH-2024-1602-06

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